Polyphenols are compounds found in Nature that, according to a wide bibliography, have a high inflammatory activity.
Many of the symptoms that appear on the skin are manifested as a result of inflammatory processes or irritation.
As an example, psoriasis involves an inflammatory process that has a clinical manifestation in the skin. Emotional stress is a factor that also greatly influences the state of the skin.
The state of inflammation in the skin is also due to the increase of inflammatory cells (leukocytes) .
Dr. Mehta (Pennsilvania University) published a study in the “Archives of Dermatology” in which he used a highly sensitive imaging technique which showed that psoriasis patients have inflammation in heart, joint and liver, while the participants without psoriasis did not show increased inflammation in any of these locations.
It is known that psoriasis patients have prevalence of diabetes, psoriatic arthritis, heart problems and depression. According to the National Psoriasis Foundation, one out of four people with psoriasis have clinical depression. Up to 30% of psoriasis patients develop psoriatic arthritis, which causes joints and tendons inflammation and stiffness.
Endogenous components of the body take part in the inflammatory reaction and immune response, and they are known to be inflammatory mediators in the process. Among them, there are cytokines and eicosanoids. They act by means of adhesion to specific receptors on the cell surfaces.
COX-1 and COX-2 cyclooxygenase enzymes are among the eicosanoids.
It has been recently discovered that IL-17 and IL-23 cytokines, produced by Th 17 cells play an important role in psoriasis.
Th17 cells play a very important role in the protection of the body, they generate mediators of the interleukin IL-17 family which are an important defence mechanism against extracellular pathogens, but which can cause excessive damage to tissues. (“The IL-17 pathway as a mayor therapeutic target in autoimmune diseases”; Yan Hu et al.2010).
“Anti-IL17 agents will probably become future important psoriasis therapies (“IL-17 targeted therapies for psoriasis”; Andrea Chricozzi et al. 2013).
Likewise, IL-23 cytokine is regulator in Th 17 cells and IL-17 generation. IL-23 as well as IL-17 axis plays a vital role in some autoimmune conditions, including psoriasis and psoriatic arthritis (“The new era for the treatment of psoriasis and psoriatic arthritis, perspectives and validated strategies”; Lucia Novelli et al.2013).
(“IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis”; Chan et al. 2006).
According to Joseph J. Territo, American researcher in olive extracts, the intervention in all these mechanisms can reduce psoriasis flakes and skin erythema as well as a reduction in the inflammatory response.
Balance in your skin
Alyvium® is a natural product, clinically tested, which contains an studied and optimized combination of polyphenols and olive flavonoids, with an important antioxidant and anti-inflammatory activity, demonstrated in numerous scientific studies. A natural alternative that helps to mitigate the symptoms in the skin as a result of disorders of the immune system.